ACTL6A Polyclonal Antibody - 100 µL

Alternate_names :Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA Description :This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is f unctionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is re quired for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. Applications :WB Species_reactivity :Human, Mouse Clonality :Polyclonal Storage_Buffer :PBS with 0.02% sodium azide, 50% glycerol, pH7.3.